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1

Identification of Phenylisoxazolines as Novel and Viable Antibacterial Agents Active against Gram-Positive Pathogens

Toops, Dana S., Watt, William, Wishka, Donn G., Barbachyn, Michael R., Cleek, Gary J., Dolak, Lester A., Garmon, Stuart A., Morris, Joel, Seest, Eric P., Thomas, Richard C.

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 437 KB

english, 2003

2

Asymmetric Synthesis of an HIV Protease Inhibitor via a Novel .alpha.-Oxoketene/Ketene [4 + 2] Cycloaddition Reaction

Gammill, Ronald B., Judge, Thomas M., Phillips, Gillian, Zhang, Qingwei, Sowell, C. Gregory, Cheney, B. Vernon, Mizsak, Stephen A., Dolak, Lester A., Seest, Eric P.

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 250 KB

english, 1994

3

Coumarins as inhibitors of bacterial DNA gyrase.

ALTHAUS, IRENE W., DOLAK, LESTER, REUSSER, FRITZ

Journal:

The Journal of Antibiotics

Year:

1988

Language:

english

File:

PDF, 426 KB

english, 1988

4

Stereoselective Synthesis of Furo[2,3-c]pyridine Pyrimidine Thioethers, A New Class of Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Wishka, Donn G., Graber, David R., Seest, Eric P., Dolak, Lester A., Han, Fusen, Watt, William, Morris, Joel

Journal:

Journal of Organic Chemistry

Year:

1998

Language:

english

File:

PDF, 291 KB

english, 1998

5

Synthesis and Biological Activities of ( R )-5,6-Dihydro- N , N -dimethyl-4 H -imidazo[4,5,1- ij ]quinolin-5-amine and Its Metabolites

Heier, Richard F., Dolak, Lester A., Duncan, J. Neil, Hyslop, Deborah K., Lipton, Michael F., Martin, Iain J., Mauragis, Michael A., Piercey, Montford F., Nichols, Nanette F., Schreur, Peggy J. K. D.,

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 441 KB

english, 1997

6

N-Nitroamides and N-Nitrocarbamates. IV. Rates of Decomposition. A Case of Steric Acceleration 1

White, Emil H., Dolak, Lester A.

Journal:

Journal of the American Chemical Society

Year:

1966

Language:

english

File:

PDF, 662 KB

english, 1966

7

Structure-Based Design of Sulfonamide-Substituted Non-Peptidic HIV Protease Inhibitors

Skulnick, Harvey I., Johnson, Paul D., Howe, W. Jeffrey, Tomich, Paul K., Chong, Kong-Teck, Watenpaugh, Keith D., Janakiraman, Musiri N., Dolak, Lester A., McGrath, James P.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 2.91 MB

english, 1995

8

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

Fred L Ciske, Michael R Barbachyn, Michael J Genin, Kevin C Grega, Chi Sing Lee, Lester A Dolak, Eric P Seest, William Watt, Wade J Adams, Janice M Friis, Charles W Ford, Gary E Zurenko

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 222 KB

english, 2003

9

Novel Asymmetric Synthesis of Atropisomeric 6-Aryl Pyrazinones via an Unusual Chirality Transfer Process

Tulinsky, John, Cheney, B. Vernon, Mizsak, Stephen A., Watt, William, Han, Fusan, Dolak, Lester A., Judge, Thomas, Gammill, Ronald B.

Journal:

Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 113 KB

english, 1999

10

N-Nitroamides and N-Nitrocarbamates. III. Rotational Isomerism, Steric Effects, and Physical Properties at Low Temperatures 1

White, Emil H., Chen, Mark C., Dolak, Lester A.

Journal:

Journal of Organic Chemistry

Year:

1966

Language:

english

File:

PDF, 1.09 MB

english, 1966

11

A new approach to steroid total synthesis. A nonenzymic biogenetic-like olefinic cyclization involving the stereospecific formation of five asymmetric centers

Johnson, William S., Semmelhack, Martin F., Sultanbawa, M. U. S., Dolak, Lester A.

Journal:

Journal of the American Chemical Society

Year:

1968

Language:

english

File:

PDF, 406 KB

english, 1968

12

Enzymatic phosphorylation of macrolide antibiotics.

WILEY, PAUL F., BACZYNSKYJ, LUBOMIR, DOLAK, LESTER A., CIALDELLA, JOYCE I., MARSHALL, VINCENT P.

Journal:

The Journal of Antibiotics

Year:

1987

Language:

english

File:

PDF, 397 KB

english, 1987

13

THE STRUCTURE OF RP 18, 631

Journal:

The Journal of Antibiotics

Year:

1973

Language:

english

File:

PDF, 213 KB

english, 1973

14

Structure-Based Design of Novel HIV Protease Inhibitors: Carboxamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Nonpeptidic Inhibitors

Thaisrivongs, Suvit, Watenpaugh, Keith D., Howe, W. Jeffrey, Tomich, Paul K., Dolak, Lester A., Chong, Kong-Teck, Tomich, Che-Shen C., Tomasselli, Alfredo G., Turner, Steve R.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 4.16 MB

english, 1995

15

The C-13 NMR spectrum of novobiocin.

Journal:

The Journal of Antibiotics

Year:

1976

Language:

english

File:

PDF, 1.39 MB

english, 1976

16

Structure-Based Design of Novel HIV Protease Inhibitors: Sulfonamide-Containing 4-Hydroxycoumarins and 4-Hydroxy-2-pyrones as Potent Non-Peptidic Inhibitors

Thaisrivongs, Suvit, Janakiraman, Musiri N., Chong, Kong-Teck, Tomich, Paul K., Dolak, Lester A., Turner, Steve R., Strohbach, Joseph W., Lynn, Janet C., Horng, Miao-Miao, Hinshaw, Roger R.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 468 KB

english, 1996

17

Tipranavir (PNU-140690): A Potent, Orally Bioavailable Nonpeptidic HIV Protease Inhibitor of the 5,6-Dihydro-4-hydroxy-2-pyrone Sulfonamide Class∇

Turner, Steve R., Strohbach, Joseph W., Tommasi, Ruben A., Aristoff, Paul A., Johnson, Paul D., Skulnick, Harvey I., Dolak, Lester A., Seest, Eric P., Tomich, Paul K., Bohanon, Michael J.

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 322 KB

english, 1998

18

Carbon–carbon-linked (pyrazolylphenyl)oxazolidinones with antibacterial activity against multiple drug resistant gram-positive and fastidious gram-negative bacteria

Chi Sing Lee, Debra A Allwine, Michael R Barbachyn, Kevin C Grega, Lester A Dolak, Charles W Ford, Randy M Jensen, Eric P Seest, Judith C Hamel, Ronda D Schaadt, Douglas Stapert, Betty H Yagi, Gary E

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 222 KB

english, 2001

19

Nature of the Complex Formed When Phenyl Grignard Is Added to Fenchone

Cowan, Dwaine O., Dolak, Lester A.

Journal:

Journal of Organic Chemistry

Year:

1966

Language:

english

File:

PDF, 318 KB

english, 1966

20

ChemInform Abstract: Stereoselective Synthesis of Furo[2,3-c]pyridine Pyrimidine Thioethers, a New Class of Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.

Donn G. Wishka, David R. Graber, Eric P. Seest, Lester A. Dolak, Fusen Han, William Watt, Joel Morris

Journal:

Year:

1999

Language:

english

File:

PDF, 38 KB

english, 1999

21

ChemInform Abstract: Novel Asymmetric Synthesis of Atropisomeric 6-Aryl Pyrazinones via an Unusual Chirality Transfer Process.

John Tulinsky, B. Vernon Cheney, Stephen A. Mizsak, William Watt, Fusan Han, Lester A. Dolak, Thomas Judge, Ronald B. Gammill

Journal:

Year:

1999

File:

PDF, 36 KB

1999

22

Isolation and structure of antibiotic U-68,204, a new thiolactone.

DOLAK, LESTER A., CASTLE, THOMAS M., TRUESDELL, S. E., SEBEK, OLDRICH K.

Journal:

The Journal of Antibiotics

Year:

1986

Language:

english

File:

PDF, 2.34 MB

english, 1986

23

(−)-6-Chloro-2-[(1-furo[2,3- c ]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a New Broad Spectrum HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitor

Wishka, Donn G., Graber, David R., Kopta, Laurice A., Olmsted, Robert A., Friis, Janice M., Hosley, John D., Adams, Wade J., Seest, Eric P., Castle, Thomas M., Dolak, Lester A., Keiser, Barbara J., Ya

Journal:

Journal of Medicinal Chemistry

Year:

1998

File:

PDF, 430 KB

1998

24

A novel asymmetric synthesis of atropisomeric 6-aryl pyrazinones via an unusual chirality transfer process. New chiral ligands for the GABAA/Chloride ionophore complex

John Tulinsky, Stephen A. Mizsak, William Watt, Lester A. Dolak, Thomas Judge, Ronald B. Gammill

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 185 KB

english, 1995

25

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

Steven P. Tanis, Bruce R. Evans, James A. Nieman, Timothy T. Parker, Wendy D. Taylor, Steven E. Heasley, Paul M. Herrinton, William R. Perrault, Richard A. Hohler, Lester A. Dolak, Matthew R. Hester,

Journal:

Tetrahedron: Asymmetry

Year:

2006

Language:

english

File:

PDF, 488 KB

english, 2006

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